Diabetes is associated with increased and persistent myocardial edema in infarct segment post acute myocardial infarction

Methods Sixty patients were enrolled post AMI and underwent cardiac magnetic resonance on a GE Signa Excite, 1.5T scanner with a 8-channel receive coil at 48 hours and 3 weeks. T2 maps were computed from a previously validated cardiac-gated spiral imaging sequence with T2 preparations yielding TEs=2.9,24.3,88.2,184.2ms to assess myocardial edema. The T2* sequence was a multiecho acquisition with 8 echoes (between 1.4 and 12.7ms) acquired at TR=14.6ms. Delayed hyperenhancement was also performed. We retrospectively reviewed and stratified patients into those that did and did not have diabetes (type 1 or type 2). Results We compared 15 diabetics versus 45 non-diabetics (Table 1). Baseline characteristics including age, gender, symptom to balloon time, door to balloon time, glycoprotein IIb/IIIa inhibitor use, and thrombus aspiration use were similar in both groups. The mean T2 was higher in the infarct segment (IS) compared to remote segment (RS) in both patient groups (diabetics: 59.3ms vs 41.3ms, p<0.0001 vs non-diabetics: 52.9ms vs 40.1ms, p<0.0001). The mean T2* was similar in the IS compared to RS in both diabetics (32.1ms vs 38.0ms; p=0.11) and non-diabetics (33.9ms vs 36.7ms; p=0.09). The mean T2 was significantly higher in the IS of diabetic patients versus non-diabetics (59.3ms vs 52.9ms; p=0.03). The mean T2* was equivalent in the IS of both patient groups (32.1ms vs 33.9ms; p=0.59). At 3 weeks, the mean T2 remained significantly higher in the IS of diabetic patients versus non-diabetics (56.6ms vs 51.2ms; p=0.04). At this time interval, the mean T2* was equivalent in the IS of both patient groups (37.1ms vs 37.0ms; p=0.96).